Lectin from Canavalia ensiformis, lyophil., SERVA

Opis towaru

Mitogenic lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A (ConA) binds to D-glucose, D-mannose and sterically related sugars in glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures.
It has potential anticancer effects due to mitogenic activity with lymphocytes and cancer cells. When administered, concanavalin A binds to glycoproteins of the cell membrane, inducing autophagy when it eventually enters the cell. Simultaneously, it triggers inflammation of tumorous cells, causing an immune response targeted against those cells. This simultaneous induction of immune response and autophagy makes it a potentially potent and novel cancer treatment. It is also used for studies of immune regulation across various cell types.

Concanavalin A from jack bean
M_r 110 000

CAS No. 11028-71-0

Storage Temperature: +2 °C to +8 °C