3-Isobutyl-1-methylxanthine, research grade, SERVA

Opis towaru

3-Isobutyl-1-methylxanthine (IBMX) is one of the most potent and nonspecific inhibitors of cyclic nucleotide phosphodiesterases (cAMP- and cGMP-PDE). The increase in cAMP level because of phosphodiesterase inhibition by IBMX activates protein kinase A (PKA), leading to decreased proliferation, increased differentiation, and induction of apoptosis. The inhibitor induces calcium release from intracellular stores in sensory neurons.
IBMX has been used as a culture medium supplement for inducing adipogenic differentiation, for 3T3-L1 preadipocyte differentiation and in the differentiation of mesenchymal stem cells (MSC).
Soluble in ethanol.

IBMX, 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
C₁₀H₁₄N₄O₂

M_r 222.2

CAS No. 28822-58-4 

Assay (NMR): min. 99.0 %
MP: 200 - 203 °C

Storage Temperature: +15 °C to +30 °C